Rare Manifestation of Granulomatosis With Polyangiitis

Introduction: Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is a multisystem disorder that mainly involves airways and kidneys. Oral GPA may present as ulcerations or strawberry gingivitis. Early diagnosis and intervention are crucial for overall prognosis. Case Presentation: An unusual case of oral GPA manifested by chronic localized inflammation, leading to failure of dental implants in an elderly woman, is presented. Diagnosis was based on antineutrophil cytoplasmic testing and histopathologic evidence of necrotizing vasculitis. Disease remission was achieved with cyclophosphamide and steroids. Conclusion: Familiarity with oral manifestations of GPA will help dentists and oral surgeons diagnose and treat early or incipient GPA without delay.