CHRONOPHARMACOKINETIC STUDY OF A NEW IMMUNOSUPPRESSIVE AGENT, FK-506, IN MICE

被引：12
|
作者：
FUJIMURA, A
SHIGA, T
OHASHI, K
EBIHARA, A
机构：
[1] Department of Clinical Pharmacology, Jichi Medical School, Kawachi-gun, Tochigi 329-04, Minamikawachi-machi
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1993年 / 61卷 / 02期
关键词：
CHRONOPHARMACOLOGY; IMMUNOSUPPRESSANT; FK-506;
D O I：
10.1254/jjp.61.137
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chronopharmacokinetic profiles of a new immunosuppressive agent, FK 506, were examined in mice. FK 506 (I mg/kg) was given orally at 10 AM (day trial) or 10 PM (night trial) once a day for 7 days. Blood samples for measurement of FK 506 concentration in whole blood were obtained just before and at 1, 2, 3, 4, 6, 8 and 12 hr after the final dosage. The time to maximum concentration was shorter and the maximum concentration was greater in the night trial than in the day trial. These findings suggest that absorption of FK 506 is faster and its blood concentration is higher in the night trial.
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收藏
页码：137 / 139
页数：3
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