SQUAMOUS-CELL CARCINOMA ANTIGEN IS A POTENT INHIBITOR OF CYSTEINE PROTEINASE CATHEPSIN-L

被引：58
|
作者：
TAKEDA, A [1 ]
YAMAMOTO, T [1 ]
NAKAMURA, Y [1 ]
TAKAHASHI, T [1 ]
HIBINO, T [1 ]
机构：
[1] SHISEIDO RES CTR, KANAZAWA KU, YOKOHAMA, KANAGAWA 227, JAPAN
来源：
FEBS LETTERS | 1995年 / 359卷 / 01期
关键词：
SQUAMOUS CELL CARCINOMA ANTIGEN (SCCA); SERPIN; PROTEINASE INHIBITOR; CATHEPSIN L;
D O I：
10.1016/0014-5793(94)01456-B
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non-competitively inhibited human cathepsin L with a K-i of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells.
引用
收藏
页码：78 / 80
页数：3
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