SUSTAINED-RELEASE TABLETS OF THEOPHYLLINE

被引：8
|
作者：
SANGHAVI, NM
KAMATH, PR
AMIN, DS
机构：
[1] Department of Chemical Technology, Matunga, Bombay
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 11期
关键词：
D O I：
10.3109/03639049009025791
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sustained release tablets of theophylline (anhydrous) were prepared using hydrophilic polymers (Methyl Cellulose, Methocel K4M and K15M) and hydrophobic polymers (ethyl cellulose, cellulose acetate). In addition water soluble adjuvants were used to modify release rate. With methocel, rapid gelling was observed and release was near zero-order, whereas with hydrophobic polymers release followed Fickian law of diffusion. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码：1843 / 1848
页数：6
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