INHIBITORY EFFECT OF TETRAHYDROBERBERINE ON PLATELET-AGGREGATION AND THROMBOSIS

被引：0
|
作者：
XUAN, B [1 ]
WANG, W [1 ]
LI, DX [1 ]
机构：
[1] NANJING MED COLL,DEPT PATHOL,NANJING 210029,PEOPLES R CHINA
来源：
ACTA PHARMACOLOGICA SINICA | 1994年 / 15卷 / 02期
关键词：
BERBERINES; PLATELET AGGREGATION; THROMBOXANE B-2; THROMBOSIS; ASPIRIN; ARACHIDONIC ACID; ADENOSINE DIPHOSPHATE; COLLAGEN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tetrahydroberberine (THB), an alkaloid extracted from Corydalis ambigua, inhibited the rabbit platelet aggregation triggered by arachidonic acid (AA), ADP, and collagen with IC50 of 0.86, 1.31, and 1.10 mmol.L(-1), respectively. THB reduced the thromboxane B-2(TXB(2)) generation in rabbit platelet-rich plasma triggered by AA THB 30 mg.kg(-1).d(-1) ip for 3 or 5 d restrained the ADP-induced platelet aggregation in rats. THB 30 mg.kg(-1).d(-1) ip for 1, 3, or 5 d inhibited the AA-induced platelet aggregation in rats. THB 15-30 mg.kg(-1) iv showed an inhibition of venous thrombosis in rats. The results show that THB is a patent inhibitor of platelet aggregation in vitro and in vivo and is a promising antithrombotic drug.
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页码：133 / 135
页数：3
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