REACTIVITY OF PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE-PEROXIDASE WITH MEMBRANE AND LIPOPROTEIN LIPID HYDROPEROXIDES

被引：72
|
作者：
MAIORINO, M [1 ]
THOMAS, JP [1 ]
GIROTTI, AW [1 ]
URSINI, F [1 ]
机构：
[1] MED COLL WISCONSIN,DEPT BIOCHEM,MILWAUKEE,WI 53226
来源：
FREE RADICAL RESEARCH COMMUNICATIONS | 1991年 / 12-3卷
关键词：
LIPID HYDROPEROXIDES; GLUTATHIONE; SE-PEROXIDASES;
D O I：
10.3109/10715769109145777
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A comparative study has been carried out on the general reactivity of lipid hydroperoxides in liposornes, biological membranes and lipoproteins with two Se-dependent peroxidases: Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX). While PHGPX reduces all hydroperoxides derived from phospholipids, cholesterol and cholesterol esters, GPX reduces only fatty acid hydroperoxides released after treatment of phospholipid hydroperoxides with phospholipase A,. These findings highlight the role of PHGPX in protecting biomembranes from peroxidative damage and add new insight into how cholesterol hydroperoxides are detossified in cells. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：131 / 135
页数：5
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