Haplotype analysis of DRD2 and ANKK1 gene polymorphisms in alcohol dependence

被引：0
|
作者：
Kucharska-Mazur, Jolanta [1 ]
Grzywacz, Anna [1 ]
Pelka-Wysiecka, Justyna [1 ]
Samochowiec, Agnieszka [1 ,2 ]
Rommelspacher, Hans [3 ]
Samochowiec, Jerzy [1 ]
机构：
[1] Pomeranian Med Univ, Dept Psychiat, 26 Broniewskiego Str, PL-71460 Szczecin, Poland
[2] Univ Szczecin, Dept Clin Psychol & Psychoprophylaxis, 69 Krakowska Str, PL-71004 Szczecin, Poland
[3] Free Univ Berlin, Dept Clin Neurobiol, Eschenallee 3, D-14050 Berlin, Germany
来源：
ARCHIVES OF PSYCHIATRY AND PSYCHOTHERAPY | 2012年 / 14卷 / 02期
关键词：
STRP; haplotype; alcohol dependence; dopamine; genes;
D O I：
暂无
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Aim. The aim of the study was to prove the hypothesis that the DRD2 and ANKK1 gene haplotypes, containing the polymorphic variant associated with reduced DRD2 availability predisposes to a severe form of alcohol dependence. Methods. The authors studied haplotypes of 3 SNPs (rs 1799732, rs 6276, rs 1800497) and one DRD2 intron 2 STRP (dinucleotide microsatellite polymorphism) in 85 male alcoholics. Results. Data have shown that the haplotypes are more common in the withdrawal without complications subgroup and more common in the withdrawal with complications (delirium or/and seizures) subgroup. Conclusion. The results do not confirm the initial hypothesis but suggest a discriminative role of STRP in the severity of alcohol dependence.
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页码：5 / 10
页数：6
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