BRYOSTATINS - THE ASYMMETRIC-SYNTHESIS OF THE C-1-C-9 AND C-17-C-27 FRAGMENTS

被引：0

作者：

DEBRABANDER, J ^{[1
]}

VANDEWALLE, M ^{[1
]}

机构：

[1] STATE UNIV GHENT,DEPT ORGAN CHEM,ORGAN SYNTH LAB,B-9000 GHENT,BELGIUM

来源：

SYNTHESIS-STUTTGART | 1994年 / 08期

关键词：

MARINE NATURAL PRODUCTS; D-PANTOLACTONE; D-ISOBUTYL LACTATE; DIASTEREOSELECTIVITY IN ALLYLATION; ALDOL AND REDUCTION REACTIONS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construction of the fragments C-1-C-9 3 and C-17-C-27 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described. The usefulness of the ''chiron'' approach is illustrated with the synthesis of these fragments from, respectively, D-pantolactone (6) and D-isobutyl lactate (23) as chiral templates.

引用

页码：855 / 865

页数：11

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