EFFECTS OF ETHANOL EXPOSURE ON THE EMBRYO FETUS - EXPERIMENTAL CONSIDERATIONS, MECHANISMS, AND THE ROLE OF PROSTAGLANDINS

被引:29
|
作者
SMITH, GN
PATRICK, J
SINERVO, KR
BRIEN, JF
机构
[1] UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT OBSTET & GYNAECOL,LONDON N6A 4V2,ONTARIO,CANADA
[2] QUEENS UNIV,FAC MED,DEPT PHARMACOL & TOXICOL,KINGSTON K7L 3N6,ONTARIO,CANADA
关键词
ALCOHOL; ETHANOL; EMBRYO; FETUS; PROSTAGLANDINS;
D O I
10.1139/y91-082
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The purpose of this review is to critically examine the effects of ethanol on the embryo-fetus. There has been a tremendous amount of human epidemiological and experimental animal research on the characterization of the anomalies produced by chronic prenatal ethanol exposure and the identification of critical periods of vulnerability and critical amounts of ethanol necessary to produce fetal effects and (or) abnormal development. Few studies have examined the underlying mechanism(s) of the action of ethanol, and even fewer studies have examined the effects of single-dose ethanol exposure on the embryo-fetus. In this review, the current state of knowledge of the effects of chronic use of ethanol on the embryo-fetus is summarized. The primary focus of the review is on the embryonic-fetal effects of acute ethanol exposure, with particular emphasis on the ethanol-induced suppression of fetal breathing movements, as this effect appears to be a very sensitive index of acute exposure of the near-term fetus to ethanol. Factors to be considered in the selection of experimental animals to investigate the mechanism of action of ethanol and to study the acute effects of ethanol are discussed. Postulated mechanisms of action of ethanol on the embryo-fetus are evaluated with a focus on the role of prostaglandins. Finally, future directions in this field of research are proposed.
引用
收藏
页码:550 / 569
页数:20
相关论文
共 50 条
  • [1] Differential gene profiles in developing embryo and fetus after in utero exposure to ethanol
    Lee, RD
    Rhee, GS
    An, SM
    Kim, SS
    Kwack, SJ
    Seok, JH
    Chae, SY
    Park, CH
    Yoon, HJ
    Cho, DH
    Kim, HS
    Park, KL
    [J]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2004, 67 (23-24): : 2073 - 2084
  • [2] Differential gene profiles in developing embryo and fetus after in utero exposure to ethanol
    Kwack, S. J.
    Lee, R. D.
    Kim, S. S.
    Rhee, G. S.
    Seok, J. H.
    Chae, S. Y.
    Kang, J. S.
    Ju, H. -Y.
    Lee, S. H.
    Cho, D. H.
    [J]. TOXICOLOGY LETTERS, 2005, 158 : S126 - S127
  • [3] Physiologic effects of acute ethanol exposure in the ovine fetus and mother
    Dalitz, P
    Cock, ML
    Henschke, PN
    Rees, SM
    Harding, R
    [J]. PEDIATRIC RESEARCH, 2004, 55 (04) : 428A - 428A
  • [4] Effects of combined exposure to ethanol and vitamin A on rat fetus tongue
    Franco, RL
    Mattos, MGC
    Lopes, RA
    Semprini, M
    Sala, MA
    Watanabe, I
    [J]. JOURNAL OF DENTAL RESEARCH, 2001, 80 (04) : 1114 - 1114
  • [5] Mechanisms Involved in Porcine Early Embryo Survival following Ethanol Exposure
    Page-Lariviere, Florence
    Campagna, Celine
    Sirard, Marc-Andre
    [J]. TOXICOLOGICAL SCIENCES, 2017, 156 (01) : 289 - 299
  • [6] PHYSIOLOGICAL AND PULMONARY EFFECTS OF ETHANOL (EtOH) EXPOSURE ON THE FETUS DURING LATE GESTATION
    Harding, Richard
    Kenna, Kelly
    Sozo, Foula
    Maritz, Gert
    Stacy, Victoria
    Brew, Nadine
    Walker, David
    DeMatteo, Robert
    Bocking, Alan
    Brien, James
    [J]. JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009, 59 : 277 - 277
  • [7] EFFECTS OF ACUTE ETHANOL EXPOSURE USING INVITRO RAT EMBRYO CULTURES
    WALSH, DA
    MCEWEN, SE
    WEBSTER, WS
    LIPSON, AH
    [J]. TERATOLOGY, 1981, 23 (02) : A68 - A68
  • [8] Long-term effects of nutritional programming of the embryo and fetus: Mechanisms and critical windows
    Symonds, Michael E.
    Stephenson, Terence
    Gardner, David S.
    Budge, Helen
    [J]. REPRODUCTION FERTILITY AND DEVELOPMENT, 2007, 19 (01) : 53 - 63
  • [9] REPAIR OF MUCOSAL DAMAGE INDUCED BY ETHANOL IN THE RAT STOMACH - EFFECTS OF CONCENTRATION, EXPOSURE PERIOD AND PROSTAGLANDINS
    TAKEUCHI, K
    NISHIWAKI, H
    OSANO, H
    EBARA, S
    OKABE, S
    [J]. DIGESTION, 1988, 40 (01) : 1 - 10
  • [10] MECHANISMS OF THE BEHAVIORAL-EFFECTS OF INTERLEUKIN-1 - ROLE OF PROSTAGLANDINS AND CRF
    BLUTHE, RM
    CRESTANI, F
    KELLEY, KW
    DANTZER, R
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 650 : 268 - 275