MOLECULAR-CLONING OF A WIDELY EXPRESSED HUMAN HOMOLOG FOR THE DROSOPHILA TRP GENE

被引：280

作者：

ZHU, X

CHU, PB

PEYTON, M

BIRNBAUMER, L

机构：

来源：

FEBS LETTERS | 1995年 / 373卷 / 03期

关键词：

TRANSIENT RECEPTOR POTENTIAL; CALCIUM INFLUX CHANNEL; CA2+ SIGNALING;

D O I：

10.1016/0014-5793(95)01038-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Drosophila transient receptor potential (trp) gene and its homologue, trpl, have been suggested to mediate calcium entry during the insect's phototransduction process. We isolated a human cDNA, human trp-1 (Htrp-1), encoding a polypeptide of 793 amino acids that is 37% identical (62% similar) to Drosophila trp and trpl, Northern analysis showed that the Htrp-1 transcript is approximately 5.5 kb and expressed in most human tissues, with higher amounts in ovary, testis, heart, and brain, Isolation of Htrp-1 suggests that a tip-type protein is present in mammals and should provide a useful tool in studying calcium-depletion induced calcium influx processes.

引用

页码：193 / 198

页数：6

共 50 条

[1] MOLECULAR-CLONING OF A HUMAN HOMOLOG OF DROSOPHILA ENHANCER OF SPLIT
SCALA, LA
TIRUMALAI, PT
PIPARO, KE
HOWELLS, RD
[J]. FASEB JOURNAL, 1994, 8 (07): : A1419 - A1419
[2] MOLECULAR-CLONING OF A DROSOPHILA-MELANOGASTER GENE CODING FOR AN HOMOLOG OF HUMAN CARBOXYPEPTIDASE-E
BERNASCONI, P
[J]. ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 1994, 27 (03) : 169 - 178
[3] ISOLATION OF A HUMAN HOMOLOG OF THE DROSOPHILA TRP GENE
ZHU, X
CHU, PB
BIRNBAUMER, L
[J]. FASEB JOURNAL, 1995, 9 (06): : A1381 - A1381
[4] MOLECULAR-CLONING AND EXPRESSION OF A MURINE HOMOLOG OF THE HUMAN POLIOVIRUS RECEPTOR GENE
MORRISON, ME
RACANIELLO, VR
[J]. JOURNAL OF VIROLOGY, 1992, 66 (05) : 2807 - 2813
[5] MOLECULAR-CLONING OF THE DROSOPHILA HOMOLOG OF THE RAT RIBOSOMAL-PROTEIN L11 GENE
LAROCHELLE, S
SUTER, B
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1995, 1261 (01): : 147 - 150
[6] MOLECULAR-CLONING OF A DROSOPHILA DIACYLGLYCEROL KINASE GENE THAT IS EXPRESSED IN THE NERVOUS-SYSTEM AND MUSCLE
MASAI, I
HOSOYA, T
KOJIMA, SI
HOTTA, Y
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) : 6030 - 6034
[7] MOLECULAR-CLONING OF A MOUSE MELANOCORTIN-5 RECEPTOR GENE WIDELY EXPRESSED IN PERIPHERAL-TISSUES
LABBE, O
DESARNAUD, F
EGGERICKX, D
VASSART, G
PARMENTIER, M
[J]. BIOCHEMISTRY, 1994, 33 (15) : 4543 - 4549
[8] MOLECULAR-CLONING OF THE HUMAN CHOLECYSTOKININ GENE
KATO, K
TAKAHASHI, Y
MATSUBARA, K
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 448 (JUL) : 613 - 615
[9] MOLECULAR-CLONING OF THE HUMAN GASTRIN GENE
KATO, K
HAYASHIZAKI, Y
TAKAHASHI, Y
HIMENO, S
MATSUBARA, K
[J]. NUCLEIC ACIDS RESEARCH, 1983, 11 (23) : 8197 - 8203
[10] MOLECULAR-CLONING OF AN INVERTEBRATE GLUTAMATE RECEPTOR SUBUNIT EXPRESSED IN DROSOPHILA MUSCLE
SCHUSTER, CM
ULTSCH, A
SCHLOSS, P
COX, JA
SCHMITT, B
BETZ, H
[J]. SCIENCE, 1991, 254 (5028) : 112 - 114

← 1 2 3 4 5 →