QUATERNARY AMMONIUM GROUPS ARE NOT CRUCIAL FOR THE ALLOSTERIC EFFECT OF GALLAMINE ON THE HUMAN M2 MUSCARINIC RECEPTOR

被引：0
|
作者：
VANHIJFTE, L [1 ]
ZERR, V [1 ]
HIBERT, M [1 ]
VANGIERSBERGEN, PLM [1 ]
机构：
[1] MARION MERRELL DOW RES INST,F-67080 STRASBOURG,FRANCE
来源：
MEDICINAL CHEMISTRY RESEARCH | 1995年 / 5卷 / 06期
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D O I：
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An analog of gallamine was synthesized which might covalently bind to the allosteric site on the m(2) muscarinic receptor. During the course of the pharmacological evaluation of this new alkylating agent it was discovered that also non-quaternary analogs of gallamine cause an allosteric modulation of H-3-N-methylscopolamine (H-3-NMS) binding to the muscarinic m2 receptors expressed in A9L cells.
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页码：449 / 454
页数：6
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