SAFETY AND CELLULAR AND HUMORAL IMMUNE-RESPONSES OF A BOOSTER DOSE OF VARICELLA VACCINE 6 YEARS AFTER PRIMARY IMMUNIZATION

被引：50

作者：

WATSON, B

ROTHSTEIN, E

BERNSTEIN, H

ARBETER, A

ARVIN, A

CHARTRAND, S

CLEMENTS, D

KUMAR, ML

REISINGER, K

BLATTER, M

STARR, SE

STAEHLE, B

NGAI, A

WHITE, CJ

机构：

[1] TEMPLE UNIV,SCH MED,PHILADELPHIA,PA

[2] ST CHRISTOPHERS HOSP CHILDREN,PHILADELPHIA,PA

[3] PENNRIDGE PEDIAT ASSOCIATES,ALLENTOWN,PA

[4] MERCK RES LABS,W POINT,PA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 01期

关键词：

D O I：

10.1093/infdis/172.1.217

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Four hundred nineteen children and adolescents immunized with live varicella vaccine 4-6 years earlier were enrolled in a study to evaluate the safety and immune response to a booster dose containing similar to 3300 pfu of virus. Of the subjects, 99% (414/419) maintained antibody to varicella tester virus (VZV) with a geometric mean titer of 25.7 and mean stimulation index (SI) for VZV-specific lymphoproliferation response of 40.3 +/- 5.3 (SE). Some 7-10 days after the booster immunization, seropositivity rates increased to 100% (302/302), and GMT was 143.6 (anamnestic response). At 6 weeks after the booster inoculation, a subset of subjects had 100% seropositivity (74/74) with a GMT of 218.8 and an SI of 58.6. After 3 months, seropositivity was 100% (358/358), GMT was 119.0, and SI was 61.4.

引用

页码：217 / 219

页数：3

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