DEVELOPMENT AND VALIDATION OF STABILITY INDICATING SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM

被引：0
|
作者：
Panigrahy, Uttam Prasad [1 ]
Swetha, M. Divya [1 ]
机构：
[1] Malla Reddy Coll Pharm, Dept Pharmaceut Anal & Qual Assurance, Secunderabad, Andhra Pradesh, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2013年 / 4卷 / 10期
关键词：
UV Spectrophotometric; Rizatriptan Benzoate; Correlation coefficient;
D O I：
10.13040/IJPSR.0975-8232.4(10).4046-50
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at lambda(max) 278nm and the drug proved linear in the range of 10-80 mu g/ml, with a good correlation coefficient of 0.9997. Percentage purity was found to be 99.94% and an excellent mean recovery (98.65%-100.7%). The method was validated statistically and it can be employed for the routine analysis of Rizatriptan benzoate in marketed formulations.
引用
收藏
页码：4046 / 4050
页数：5
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