INTERACTIONS OF SPIRONOLACTONE WITH (+)-[H-3]-ISRADIPINE AND (-)-[H-3]-DESMETHOXYVERAPAMIL BINDING-SITES IN VASCULAR SMOOTH-MUSCLE

被引：5

作者：

MIRONNEAU, J

SAYET, I

RAKOTOARISOA, L

DACQUET, C

MIRONNEAU, C

机构：

[1] Lab. Physiologie Cellulaire, INSERM Jeune Formation 88-13, Universite de Bordeaux II, 33076 Bordeaux Cedex

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 101卷 / 01期

关键词：

D O I：

10.1111/j.1476-5381.1990.tb12077.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spironolactone partially inhibited the specific binding of (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil to vascular smooth muscle membranes. It is suggested that spironolactone interacts at a binding site of the calcium channel complex and allosterically modulates ligand binding at receptor sites in the channel.

引用

页码：6 / 7

页数：2

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