PORCINE LEUKOCYTE INTERFERON EXHIBITS CLOSE ANTIGENIC RELATEDNESS TO HUMAN INTERFERON-ALPHA-2, BUT NOT TO HUMAN INTERFERON-ALPHA-1

被引：2
|
作者：
KARAYIANNIVASCONCELOS, G [1 ]
BORECKY, L [1 ]
KONTSEK, P [1 ]
机构：
[1] SLOVAK ACAD SCI, INST VIROL, CS-84246 BRATISLAVA, CZECHOSLOVAKIA
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1993年 / 38卷 / 3-4期
关键词：
D O I：
10.1016/0165-2427(93)90093-J
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
As reported by others using polyclonal antisera, natural human and porcine interferons (IFN)-alpha are antigenically related. Using monoclonal antibodies (mAb) in neutralization and ELISA experiments, we found differences in the subtype/antigenic composition between virus-induced porcine and human leukocyte preparations. Human leukocyte IFN-alpha contains two major antigenically distinct subtypes, IFN-alpha 1 and IFN-alpha 2. However, swine leukocytes produced only a single predominant species of IFN-alpha with high antigenic homology to human IFN-alpha 2. Moreover, we were unable to detect close antigenic relatedness between recombinant porcine and human IFN-alpha 1 subtypes.
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页码：359 / 365
页数：7
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