LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN BLOOD OF RHEUMATOID ARTHRITIS PATIENTS

被引：0
|
作者：
Vijayakumar, D. [1 ]
Suresh, K. [1 ]
Manoharan, S. [1 ]
机构：
[1] Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India
来源：
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY | 2006年 / 21卷 / 01期
关键词：
Rheumatoid arthritis; lipid peroxidation; antioxidants;
D O I：
10.1007/BF02913075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The main objective of the study was to assess the oxidative stress in plasma and erythrocytes of rheumatoid arthritis patients by measuring the levels of thiobarbituric acid reactive substances (TBARS), non-enzymatic antioxidants (vitamin E, C and reduced glutathione) and enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHPx)]. This study has been conducted on twenty-two adult female rheumatoid arthritis patients and an equal number of healthy subjects. Elevated lipid peroxidation and multidirectional changes in the antioxidant defence system were noticed in patients with rheumatoid arthritis. The enhanced lipid peroxidation accompanied by disturbance in antioxidant status indicates that rheumatoid arthritis patients are more prone to free radical mediated oxidative damage.
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页码：104 / +
页数：5
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