The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism

被引：29

作者：

Gordon, Donna M. ^{[1
]}

Santos, Janine Hertzog ^{[2
]}

机构：

[1] Mississippi State Univ, Dept Biol Sci, Mississippi State, MS 39762 USA

[2] UMDNJ, New Jersey Med Sch, Dept Pharmacol & Physiol, 185 South Orange Ave,Med Sci Bldg,H653, Newark, NJ 07103 USA

来源：

JOURNAL OF NUCLEIC ACIDS | 2010年 / 2010卷

关键词：

D O I：

10.4061/2010/390791

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a role in mitochondrial DNA metabolism. This paper discusses the available data on mitochondrial telomerase with particular emphasis on its effects upon the organellar DNA.

引用

页数：7

共 50 条

[1] Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA from damage
Haendeler, Judith
Goy, Christine
Droese, Stefan
Siebels, Ilka
Spyridopoulos, Ioakim
Brandt, Ulrich
CIRCULATION, 2006, 114 (18) : 328 - 329
[2] The reverse transcriptase activity of the enzyme telomerase reverse transcriptase reduces mitochondrial production of reactive oxygen species and binds to mitochondrial DNA
Haendeler, J
Goy, C
Siebels, I
Droese, S
Brandt, U
CIRCULATION, 2005, 112 (17) : U302 - U302
[3] Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage
Haendeler, Judith
Droese, Stefan
Buechner, Nicole
Jakob, Sascha
Altschmied, Joachim
Goy, Christine
Spyridopoulos, Ioakim
Zeiher, Andreas M.
Brandt, Ulrich
Dimmeler, Stefanie
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (06) : 929 - U400
[4] Defining the functions of mitochondrial Telomerase Reverse Transcriptase
Buechner, Nicole
Goy, Christine
Rabanter, Lothar Ludwig
Jakob, Sascha
Altschmied, Joachim
Haendeler, Judith
CIRCULATION RESEARCH, 2013, 113 (04)
[5] Mitochondrial function of Telomerase Reverse Transcriptase in cardiovascular aging
Ale-Agha, N.
von Ameln, F.
Zurek, M.
Eckers, A.
Goy, C.
Altschmied, J.
Haendeler, J.
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 2016, 49 : S144 - S144
[6] Mitochondrial Telomerase Reverse Transcriptase, a Target for Cardiovascular Disease?
Torimoto, Keiichi
Eguchi, Satoru
FUNCTION, 2022, 3 (05):
[7] Telomerase activity of reverse transcriptase
Ricchetti, M
Buc, H
SCIENCE, 1997, 277 (5328) : 887 - 887
[8] A Role For Mesenchymal Cell Telomerase Reverse Transcriptase In Pulmonary Fibrosis
Liu, T.
Yu, H.
Ding, L.
Wu, Z.
Gonzalez De Los Santos, F.
Liu, J.
Ullenbruch, M.
Hu, B.
Martins, V.
Phan, S. H.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
[9] The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
Masutomi, K
Possemato, R
Wong, JMY
Currier, JL
Tothova, Z
Manola, JB
Ganesan, S
Lansdorp, PM
Collins, K
Hahn, WC
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (23) : 8222 - 8227
[10] Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA
Koczor, Christopher A.
Lewis, William
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2010, 6 (12) : 1493 - 1504

← 1 2 3 4 5 →