Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases

被引：0

作者：

Ching, Alex Sik Chung ^{[1
]}

Kuhnast, Bertrand ^{[1
]}

Damont, Annelaure ^{[1
]}

Roeda, Dirk ^{[1
]}

Tavitian, Bertrand ^{[1
]}

Dolle, Frederic ^{[1
]}

机构：

[1] Serv Hosp Freder Joliot, CEA, I2BM, 4 Pl Gen Leclerc, F-91401 Orsay, France

来源：

INSIGHTS INTO IMAGING | 2012年 / 3卷 / 01期

关键词：

TSPO; Translocator protein; Neuroinflammation; Neurodegenerative diseases; Microglial activation; PET ligands;

D O I：

10.1007/s13244-011-0128-x

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Neuroinflammation is a process characterised by drastic changes in microglial morphology and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria. The continual increase in incidence of neuroinflammation and neurodegenerative diseases poses a major health issue in many countries, requiring more innovative diagnostic and monitoring tools. TSPO expression may constitute a biomarker for brain inflammation that could be monitored by using TSPO tracers as neuroimaging agents. From medical imaging perspectives, this review focuses on the current concepts related to the TSPO, and discusses briefly on the status of its PET imaging related to neuroinflammation and neurodegenerative diseases in humans.

引用

页码：111 / 119

页数：9

共 50 条

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