RAPHE PALLIDUS STIMULATION INCREASES GASTRIC CONTRACTILITY VIA TRH PROJECTIONS TO THE DORSAL VAGAL COMPLEX IN RATS

被引：48

作者：

GARRICK, T

PRINCE, M

YANG, H

OHNING, G

TACHE, Y

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, CURE, CTR GASTROENTEROL BIOL, LOS ANGELES, CA 90024 USA

[2] UNIV CALIF LOS ANGELES, SCH MED, DPET PSYCHIAT, LOS ANGELES, CA 90024 USA

[3] UNIV CALIF LOS ANGELES, SCH MED, DEPT RES, LOS ANGELES, CA 90024 USA

[4] UNIV CALIF LOS ANGELES, SCH MED, DEPT MED, LOS ANGELES, CA 90024 USA

[5] BRAIN RES INST, LOS ANGELES, CA USA

来源：

BRAIN RESEARCH | 1994年 / 636卷 / 02期

关键词：

RAPHE PALLIDUS; THYROTROPIN RELEASING HORMONE; DORSAL VAGAL COMPLEX; GASTRIC MOTILITY; GLUTAMATE; RAT;

D O I：

10.1016/0006-8993(94)91035-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of thyrotropin releasing hormone (TRH) in the dorsal vagal complex (DVC) in mediating the enhanced gastric contractility induced by glutamate (100 pmol) microinjected into the raphe pallidus (Rpa) was investigated in urethane-anesthetized rats acutely implanted with miniature strain gauge force transducers on the corpus of the stomach. Glutamate-induced stimulation of gastric contractility was dose-dependently inhibited by bilateral microinjection into the DVC of TRH antibody (0.17, 0.85 or 1.7 mu g/100 nl/site) but not by vehicle. TRH antibody microinjected into the dorsal medullary reticular field had no effect. These data indicate that activation of Rpa neurons by glutamate increases gastric motor function through TRH release in the DVC.

引用

页码：343 / 347

页数：5

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