SEQUENCE HOMOLOGY BETWEEN PURPLE ACID-PHOSPHATASES AND PHOSPHOPROTEIN PHOSPHATASES - ARE PHOSPHOPROTEIN PHOSPHATASES METALLOPROTEINS CONTAINING OXIDE-BRIDGED DINUCLEAR METAL CENTERS

被引：51
|
作者：
VINCENT, JB [1 ]
AVERILL, BA [1 ]
机构：
[1] UNIV VIRGINIA, DEPT CHEM, CHARLOTTESVILLE, VA 22901 USA
来源：
FEBS LETTERS | 1990年 / 263卷 / 02期
关键词：
Protein phosphatase; Purple acid phosphatase; Sequence homology;
D O I：
10.1016/0014-5793(90)81389-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The amino acid sequences of mammalian purple acid phosphatases and phosphoprotein phosphatases are shown to possess regions of significant homology. The conserved residues contain a high percentage of possible metal-binding residues. The phosphoprotein phosphatases 1, 2A and 2B are proposed to be iron-zinc metalloenzymes with active sites isostructural (or nearly so) with those of the purple phosphatases. © 1990.
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页码：265 / 268
页数：4
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