MODELING MARGINAL HAZARDS IN MULTIVARIATE FAILURE TIME DATA

被引:0
|
作者
LIANG, KY [1 ]
SELF, SG [1 ]
CHANG, YC [1 ]
机构
[1] FRED HUTCHINSON CANC RES CTR,SEATTLE,WA 98104
关键词
FAILURE TIME DATA; MARGINAL HAZARD; MULTIVARIATE ANALYSIS; U-STATISTICS;
D O I
暂无
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
We consider the problem of estimating relative risk parameters in the marginal distribution of failure times from a sample in which individuals are grouped into clusters and failure times for individuals within clusters may be dependent. We assume that the marginal hazard of failure for individuals within a cluster is specified by a relative risk regression model and the structure of dependence between individuals within a cluster is left unspecified. Estimating equations for the regression parameters and an estimator for the cumulative base-line marginal hazard are described. Large sample distribution theory based on a representation of the estimating functions as U-statistics is developed and results from a small simulation study are described. Two examples which originally motivated this work are presented.
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页码:441 / 453
页数:13
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