ON ESTIMATING THE DISTRIBUTION FUNCTION FOR QUALITY-OF-LIFE IN CANCER CLINICAL-TRIALS

被引：11
|
作者：
KORN, EL
机构：
[1] Biometric Research Branch, National Cancer Institute, Bethesda
来源：
BIOMETRIKA | 1993年 / 80卷 / 03期
关键词：
INFORMATIVE CENSORING; KAPLAN-MEIER ESTIMATOR; QUALITY OF LIFE; REPEATED MEASURES; SURVIVAL ANALYSIS;
D O I：
10.1093/biomet/80.3.535
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The analysis of quality-of-life data collected at periodic intervals in a cancer clinical trial must account for those patients' data that are 'missing' because of death or administrative censoring. We examine estimates of the cumulative distribution function of an interpolated area under a quality-of-life curve as summaries of the quality-of-life experience of a treatment group. A proposed estimator, although biased, offers an improvement over a Kaplan-Meier estimator that assumes incorrectly that the censoring is noninformative.
引用
收藏
页码：535 / 542
页数：8
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