CYCLODEXTRIN INCLUSION COMPLEX TO ENHANCE SOLUBILITY OF POORLY WATER SOLUBLE DRUGS: A REVIEW

被引：71
|
作者：
Chaudhary, V. B. [1 ]
Patel, J. K. [2 ]
机构：
[1] RK Univ, Sch Pharm, Rajkot, Gujarat, India
[2] Nootan Pharm Coll, Visnagar, Gujarat, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2013年 / 4卷 / 01期
关键词：
Complexation; Cyclodextrins; Bioavailability; DSC; FTIR; XRD; SEM;
D O I：
10.13040/IJPSR.0975-8232.4(1).68-76
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Low solubility compounds show dissolution rate limited absorption and hence poor absorption, distribution and target organ delivery. Improvement of aqueous solubility in such a case is valuable goal to improve therapeutic efficacy. Complexation with CDs by different methods like physical mixing, melting, kneding, spray drying, freeze drying, co-evaporation has been reported to enhance the solubility, dissolution rate and bioavability of poorly water soluble drugs. The formation of inclusion complex can be confirmed by DSC, FTIR, XRD and SEM study. This review aims to assess the use of cyclodextrines as complexing agents to enhance the solubility of poorly soluble drugs and hence to resolve the many issues associated with developing and commercializing poorly water soluble drugs.
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页码：68 / 76
页数：9
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