AN EFFICIENT ROUTE TO A KEY A-RING SYNTHON FOR 1-ALPHA,25-DIHYDROXYVITAMIN D-3 AND ITS ANALOGS

被引：51

作者：

HATAKEYAMA, S ^{[1
]}

IRIE, H ^{[1
]}

SHINTANI, T ^{[1
]}

NOGUCHI, Y ^{[1
]}

YAMADA, H ^{[1
]}

NISHIZAWA, M ^{[1
]}

机构：

[1] TOKUSHIMA BUNRI UNIV,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN

来源：

TETRAHEDRON | 1994年 / 50卷 / 47期

关键词：

D O I：

10.1016/S0040-4020(01)89344-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and highly stereoselective route to the Roche's A-ring synthon of 1 alpha,25-dihydroxyvitamin D-3 from R-(-)-epichlorohydrin has been developed utilizing double propargylation of R-(-)-epichlorohydrin and palladium(0) catalyzed intramolecular Heck type of reaction of the omega-vinyl(Z)-iodoalkene as key steps.

引用

页码：13369 / 13376

页数：8

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