LIPOPROTEIN (A) IN A RANDOMLY SELECTED 25-64 YEAR-OLD POPULATION - THE NORTHERN SWEDEN MONICA STUDY

被引：60

作者：

SLUNGA, L ^{[1
]}

ASPLUND, K ^{[1
]}

JOHNSON, O ^{[1
]}

DAHLEN, GH ^{[1
]}

机构：

[1] UMEA UNIV HOSP,DEPT CLIN CHEM,S-90185 UMEA,SWEDEN

来源：

JOURNAL OF CLINICAL EPIDEMIOLOGY | 1993年 / 46卷 / 07期

关键词：

LIPOPROTEIN (A); LIPIDS; AGE AND SEX DISTRIBUTION; EPIDEMIOLOGY; FIBRINOGEN; MENOPAUSE;

D O I：

10.1016/0895-4356(93)90034-X

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Lipoprotein (a) (Lp (a)) was determined in 1527 individuals participating in the Northern Sweden WHO MONICA project for monitoring of cardiovascular risk factors in the general population. Subjects were randomly selected and stratified according to sex and age. A weak but significant relation between Lp (a) and increasing age was found in both sexes (p < 0.01). Menopausal status was the strongest independent predictor of Lp (a) level in women (p = 0.010). Fibrinogen was independently related to Lp (a) in both men and women (p < 0.05). An inverse relation between waist-to-hip ratio and Lp (a) was found in men (p < 0.01). Hypertensive subjects treated with diuretics had significantly higher Lp (a) than hypertensives on other agents (p < 0.05). Only a minor proportion of Lp (a) variance could be explained by lifestyle factors, which supports the contention that genetic factors primarily control Lp (a) level.

引用

页码：617 / 624

页数：8

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