OXYGEN-FREE RADICALS IMPAIR FRACTURE-HEALING IN RATS

被引：1
|
作者：
GOKTURK, E
TURGUT, A
BAYCU, C
GUNAL, I
SEBER, S
GULBAS, Z
机构：
[1] UNIV OSMANGAZI, FAC MED, DEPT HISTOL & EMBRYOL, ESKISEHIR 26480, TURKEY
[2] UNIV OSMANGAZI, FAC MED, DEPT HEMATOL, ESKISEHIR 26480, TURKEY
来源：
ACTA ORTHOPAEDICA SCANDINAVICA | 1995年 / 66卷 / 05期
关键词：
D O I：
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中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
We studied the effect of oxygen-free radicals on fracture healing. 30 male rats were divided into 2 groups: 15 rats were given saline 5 mL/kg i.p. (control group) and 15 were given zymosan 100 mg/kg i.p. to induce oxygen-free radicals through stimulation of NADPH oxidase in polymorphonuclear leucocytes. 1 hour later, the right forelimbs of the rats were broken by light manual compression. These treatments were given once a day until the fifth postfracture day. All rats were killed on day 22, and histological sections of the radius and ulna were examined without knowledge of the treatment given. The administration of zymosan impaired the fracture healing and therefore oxygen-free radicals appear to play an important role in fracture healing.
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页码：473 / 475
页数：3
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