STRUCTURE-ACTIVITY-RELATIONSHIPS OF SULFUR-CONTAINING TRIAZOLE ANTIFUNGALS

被引：13
|
作者：
MIYAUCHI, H
KOZUKI, K
TANIO, T
OHASHI, N
机构：
[1] Research Center, Sumitomo Pharmaceuticals Co., Ltd., Konohana-ku, Osaka, 554, 1-98
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 14期
关键词：
D O I：
10.1016/0960-894X(95)00241-K
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Alkylthio and alkylsulfonyl derivatives of antifungal SM-8668 (3) were synthesized and estimated for their activities in vitro and in vivo. Derivatives having pentylthio, heptylthio or nonylthio group showed potent activities against both candidiasis and aspergillosis. The introduction of hydroxyl group at the end of their alkyl chain made their activities stronger.
引用
收藏
页码：1479 / 1482
页数：4
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