EVALUATION OF ANTIULCER ACTIVITY OF CALOTROPIS GIGANTEA R.Br LEAVES

被引：4
|
作者：
Swapna, P. [2 ]
Robertson, Stellaa [1 ]
Elumalai, A. [2 ]
Eswaraiah, M. Chinna [2 ]
Nirmala, K. [2 ]
机构：
[1] SRM Coll Pharm, Dept Pharmacognosy, Chennai 603203, Tamil Nadu, India
[2] Anurag Pharm Coll, Dept Pharmacognosy, 2 Ananthagiri, Nalgonda 508206, Andhra Pradesh, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2011年 / 2卷 / 11期
关键词：
Ethanolic extract; Calotropis gigantea; Pylorus ligation; Ethanol induced ulcer model; Ulcer index; Omeprazole;
D O I：
10.13040/IJPSR.0975-8232.2(11).2938-41
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The antiulcer activity of ethanolic extract of Calotropis gigantea R.Br leaves (EECG) was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Ethanolic extract of Calotropis gigantea at a dose of 150 and 300mg/ kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (150mg/ kg and 300mg/ kg) showed significant (p<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that EECG have potential anti-ulcer activity in both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.
引用
收藏
页码：2938 / 2941
页数：4
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