DECREASED ERYTHROCYTE CHOLESTEROL PHOSPHOLIPID RATIO IN UNTREATED PATIENTS WITH ESSENTIAL-HYPERTENSION

被引：15
|
作者：
RONQUIST, G
FRITHZ, G
GUNNARSSON, K
ARVIDSON, G
机构：
[1] CENT HOSP ESKILSTUNA,DEPT INTERNAL MED,ESKILSTUNA,SWEDEN
[2] UNIV UPPSALA,CTR BIOMED,DEPT MED & PHYSIOL CHEM,S-75105 UPPSALA,SWEDEN
来源：
JOURNAL OF INTERNAL MEDICINE | 1992年 / 232卷 / 03期
关键词：
CHOLESTEROL; ERYTHROCYTE MEMBRANE; HYPERTENSION; PHOSPHOLIPIDS;
D O I：
10.1111/j.1365-2796.1992.tb00579.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The erythrocyte cholesterol/phospholipid ratio was determined in eight patients with untreated essential hypertension and compared with that of eight age-matched control subjects. The ratio was significantly lower in patients (Wilcoxon's paired rank test; P < 0.01), and a correlation existed between the ratio and serum cholesterol concentration in patients (r = 0.63) but not in controls (r = 0.02). A reduction in the cholesterol/phospholipid ratio may play a direct role in destabilizing the plasma membrane, which will in turn result in an increase in membrane permeability in essential hypertension.
引用
收藏
页码：247 / 251
页数：5
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