THE EFFECT OF CHRONIC CLOZAPINE AND HALOPERIDOL ON BASAL DOPAMINE RELEASE AND METABOLISM IN RAT STRIATUM AND NUCLEUS ACCUMBENS STUDIED BY INVIVO MICRODIALYSIS

被引：53
|
作者：
ICHIKAWA, J
MELTZER, HY
机构：
[1] Laboratory of Biological Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, OH 44106
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 03期
关键词：
Clozapine (chronic); Dopamine release and metabolism; Haloperidol (chronic); Microdialysis;
D O I：
10.1016/0014-2999(90)90033-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. Chronic haloperidol (2 mg/kg × 21 days) but not chronic clozapine (20 mg/kg × 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. These results differ significantly from those previously reported with in vivo voltammetry. Possible explanations are discussed. © 1990.
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页码：371 / 374
页数：4
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