EFFECT OF CRYSTALLIZATION OF THEOPHYLLINE ON PHYSICAL-PROPERTIES OF TABLETS

被引：8
|
作者：
ANDO, H
ISHII, M
KAYANO, M
WATANABE, S
机构：
[1] Pharmaceutical Development Research Laboratories, Eisai Co., Ltd., Tsukuba-shi, Ibaraki, 300-26, 1-3,r Tokodai Scheme
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 19期
关键词：
D O I：
10.3109/03639049509065903
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Tablets containing anhydrous theophylline, a hygroscopic material such as magnesium chloride or potassium acetate, and other constituents were stored for 4 and 12 weeks under 90% relative humidity at 37 degrees C. During storage, whisker-like crystals appeared on the surface of the tablets. The crystals were observed under a scanning electron microscope. Changes were found in the physical properties of these tablets: crushing strength, friability, disintegration time and dissolution rate.
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页码：2227 / 2237
页数：11
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