GLUTAMATE-GATED ION CHANNELS IN THE BRAIN - GENETIC MECHANISM FOR GENERATING MOLECULAR AND FUNCTIONAL DIVERSITY

被引：0
|
作者：
SOMMER, B
MONYER, H
WISDEN, W
VERDOORN, TA
BURNASHEV, N
SPRENGEL, R
SAKMANN, B
SEEBURG, PH
机构：
[1] UNIV HEIDELBERG, ZENTRUM MOLEK BIOL, NEUENHEIMER FELD 282, W-6900 HEIDELBERG 1, GERMANY
[2] MAX PLANCK INST MED RES, W-6900 HEIDELBERG 1, GERMANY
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 1992年 / 42-1卷 / 2A期
关键词：
BRAIN; CHEMICAL INFORMATION TRANSMISSION; ION CHANNELS; IN THE BRAIN;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
L-glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system. Most cells are responsive to glutamate which activates cation channels with different pharmacological, kinetic, and ion permeability properties. These channels play important roles in neurotransmission, memory acquisition as well as acute and chronic disorders of the brain. The present report summarizes recent knowledge on AMPA (alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid) receptors which mediate fast synaptic neurotransmission.
引用
收藏
页码：209 / 210
页数：2
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