DESORPTION CHEMICAL IONIZATION AND FIELD DESORPTION MASS-SPECTROMETRIC ANALYSIS OF ANTITUMOR CATHARANTHUS (VINCA) ALKALOIDS

被引：6
|
作者：
THIMMAIAH, KN
THOMAS, MJ
SETHI, VS
GOWDA, NMM
机构：
[1] UNIV MYSORE, DEPT POST GRAD STUDIES & RES CHEM, MYSORE 570006, KARNATAKA, INDIA
[2] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT BIOCHEM, WINSTON SALEM, NC 27103 USA
[3] UNIV TEXAS, DEPT CHEM, EL PASO, TX 79968 USA
[4] WESTERN ILLINOIS UNIV, DEPT CHEM, MACOMB, IL 61455 USA
[5] ST JUDE CHILDRENS RES HOSP, DEPT BIOCHEM & CLIN PHARMACOL, MEMPHIS, TN 38101 USA
来源：
MICROCHEMICAL JOURNAL | 1990年 / 41卷 / 02期
关键词：
D O I：
10.1016/0026-265X(90)90117-N
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Antitumor Catharanthus (Vinca) alkaloids, vinblastine and vincristine, and their chemically modified derivatives N-deformylvincristine, N-deformyl-4-deacetylvincristine, vindesine, 4-deacetylvinblastine, and 4-deacetylvincristine, after purification by high-pressure liquid chromatography were analyzed using the soft ionization technique of desorption chemical ionization mass spectrometry or field desorption mass spectrometry. The dominant signal from the free bases by these techniques was their respective protonated molecular ion. These studies suggest that these techniques can be conveniently applied for characterization of the metabolites and/or in vitro degradation products of the antitumor alkaloids. © 1990.
引用
收藏
页码：183 / 190
页数：8
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