THE EFFECT OF HALOPERIDOL ON VENTRICULAR-FIBRILLATION THRESHOLD IN PIGS

被引:11
|
作者
TISDALE, JE
KAMBE, JC
CHOW, MSS
YESTON, NS
机构
[1] UNIV CONNECTICUT,SCH PHARM,STORRS,CT 06268
[2] HARTFORD HOSP,DEPT PHARM,HARTFORD,CT 06115
[3] NEW BRITAIN GEN HOSP,DEPT SURG,NEW BRITAIN,CT 06050
[4] HARTFORD HOSP,DEPT CRIT CARE MED SURG,HARTFORD,CT 06115
[5] UNIV CONNECTICUT,SCH MED,FARMINGTON,CT 06032
来源
PHARMACOLOGY & TOXICOLOGY | 1991年 / 69卷 / 05期
关键词
D O I
10.1111/j.1600-0773.1991.tb01305.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Ventricular fibrillation has been observed in association with the administration of haloperidol. This study was designed to determine the effect of intravenous haloperidol on ventricular fibrillation threshold (VFT). VFT's were determined prior to and 15 min. following an intravenous infusion of haloperidol (50 mg administered over 10 min.) in five pigs anaesthetized with alpha-chloralose. VFT's were determined using a single stimulus method. Mean arterial pressure (MAP), heart rate (HR), and electrocardiogram (ECG) were monitored continuously. Mean VFT (mA) at baseline and following haloperidol infusion was 50.2 +/- 4.6 and 65.1 +/- 12.8, respectively (P < 0.05). Mean MAP (mmHg) at baseline and following haloperidol infusion was 127 +/- 32 and 107 +/- 23, respectively (P < 0.05). Haloperidol infusion did not significantly influence mean HR, QRS duration or corrected QT interval. Intravenous haloperidol increases VFT and decreases MAP in pigs. In this model, haloperidol may offer protection against ventricular fibrillation. Further study is required to determine the clinical significance of the antifibrillatory effect of haloperidol.
引用
收藏
页码:327 / 329
页数:3
相关论文
共 50 条
  • [1] EFFECT OF CATECHOLAMINES ON VENTRICULAR-FIBRILLATION THRESHOLD
    MURNAGHA.MF
    [J]. IRISH JOURNAL OF MEDICAL SCIENCE, 1974, 143 (05) : 305 - 305
  • [2] EFFECT OF ESMOLOL ON THE VENTRICULAR-FIBRILLATION THRESHOLD
    WALLIS, DE
    WEDEL, VA
    SCANLON, PJ
    EULER, DE
    [J]. PHARMACOLOGY, 1988, 36 (01) : 9 - 15
  • [3] THE EFFECT OF PH ON THE HYPOTHERMIC VENTRICULAR-FIBRILLATION THRESHOLD
    SWAIN, JA
    WHITE, FN
    PETERS, RM
    [J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1984, 87 (03): : 445 - 451
  • [4] EFFECT OF ALCOHOL ON VENTRICULAR-FIBRILLATION THRESHOLD IN DOGS
    KOSTIS, JB
    HORSTMANN, E
    MAVROGEORGIS, E
    RADZIUS, A
    GOODKIND, MJ
    [J]. QUARTERLY JOURNAL OF STUDIES ON ALCOHOL-PART A, 1973, 34 (04): : 1315 - 1322
  • [5] THE EFFECT OF CORDARON ON VENTRICULAR-FIBRILLATION THRESHOLD IN CATS
    STOLYARCHUK, AA
    STOROZHUK, BG
    [J]. KARDIOLOGIYA, 1982, 22 (11) : 82 - 84
  • [6] EFFECT OF CHEMICAL SYMPATHECTOMY ON VENTRICULAR-FIBRILLATION THRESHOLD
    DAWSON, AK
    LEON, AS
    [J]. FEDERATION PROCEEDINGS, 1977, 36 (03) : 1002 - 1002
  • [7] EFFECT OF SODIUM PENTOBARBITAL ON VENTRICULAR-FIBRILLATION THRESHOLD
    DAWSON, AK
    LEON, AS
    TAYLOR, HL
    [J]. FEDERATION PROCEEDINGS, 1979, 38 (03) : 1117 - 1117
  • [8] EFFECT OF NOREPINEPHRINE ON VENTRICULAR-FIBRILLATION THRESHOLD IN CAT
    BONET, J
    WALD, RW
    WAXMAN, MB
    [J]. CLINICAL RESEARCH, 1976, 24 (05): : A646 - A646
  • [9] EFFECT OF RIGHT VENTRICULAR ISOLATION AND UNILATERAL SYMPATHECTOMY ON VENTRICULAR-FIBRILLATION THRESHOLD - SURGICAL APPROACHES TO VENTRICULAR-FIBRILLATION
    DAMIANO, RJ
    TRIPP, HF
    ASANO, T
    SMALL, KW
    IDEKER, RE
    COX, JL
    [J]. SURGICAL FORUM, 1985, 36 : 230 - 232
  • [10] VENTRICULAR-FIBRILLATION THRESHOLD IN MAN
    HOROWITZ, LN
    SPEAR, JF
    JOSEPHSON, ME
    KASTOR, JA
    MACVAUGH, H
    MOORE, EN
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1977, 39 (02): : 274 - 274