Ciprofloxacin has become the treatment of choice for salmonella infections due to its clinical efficacy and the development of resistance to other antibiotics, It shortens the course of clinical disease and the period of excretion in enteric salmonella infections, has excellent in-vitro activity against all the bacterial pathogens that commonly cause infective diarrhoea (Wilcox and Spencer 1992) and side effects are uncommon. We report here the first case of autoimmune haemolytic anaemia (AIHA) associated with its use.