HAMARTOMA OF TUBER-CINEREUM AND PRECOCIOUS PUBERTY IN A 10-MONTH MALE

We report a case of a 10 month old male with true precocious puberty due to hypothalamic hamartoma. Endocrinological evaluation revealed high levels of Testosterone and LH, while FSH response to LHRH test resulted in prepubertal range. Plain computerized tomography failed in demonstrating cerebral lesions. A successive Magnetic Resonance demonstrated a sessile mass attached to the floor of the third ventricle. The children was treated with LHRH agonist with regression of secondary sex characteristics and return in the prepubertal range of values of testosterone and LH. Six months later a second Cerebral Magnetic Resonance didn't reveal any change in the dimension and in the features of the mass. The successful and the proved safety of such therapy seem suggest a non surgical approach for precious puberty due to hypothalamic hamartomas when there is an high risk in surgical removal.