NUCLEAR INTERNALIZATION AND DNA-BINDING ACTIVITIES OF INTERLEUKIN-1, INTERLEUKIN-1 RECEPTOR AND INTERLEUKIN-1 RECEPTOR COMPLEXES

被引：30

作者：

WEITZMANN, MN ^{[1
]}

SAVAGE, N ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,SCH MED,BRAIN FUNCT RES UNIT,JOHANNESBURG 2193,SOUTH AFRICA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91319-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper presents evidence to suggest that interleukin-1α as a complex with its receptor is able to express DNA binding activity. Both the interleukin-1/receptor complex and the interleukin-1 receptor appear to be able to bind to DNA, however interleukin-1 on its own showed no binding activity. Interleukin-1 was found to be internalised into the nuclei of all cells examined (EL4, MEL, HL-60, K562, THP-1 and Jurkat cells). The data suggest the possible modulation of genes by interaction of interleukin-1/receptor complexes with DNA structures. © 1992.

引用

页码：1166 / 1171

页数：6

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