THE REACTION OF ALPHA-ALKOXYALLYLPHOSPHINE OXIDES WITH ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS - AN APPROACH TO PROSTAGLANDIN PRECURSORS

被引：12
|
作者：
BIRSE, EF [1 ]
IRONSIDE, MD [1 ]
MURRAY, AW [1 ]
机构：
[1] UNIV DUNDEE,DEPT CHEM,DUNDEE DD1 4HN,SCOTLAND
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 35期
关键词：
D O I：
10.1016/0040-4039(95)01218-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The regiochemistry of the reaction of alpha-methoxyallylphosphine oxides with alpha, beta unsaturated carbonyl compounds has been studied. With 2-cyclopenten-1-ones, and using a transmetallation procedure, a nucleophilic beta-alkylation-electrophilic alpha-alkylation strategy which leads to advanced prostlgandin precursors has been developed.
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页码：6309 / 6312
页数：4
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