Effects of congenital heart disease on brain development

被引：115
|
作者：
McQuillen, Patrick S. [1 ]
Goff, Donna A. [2 ]
Licht, Daniel J. [3 ]
机构：
[1] Univ Calif San Francisco, Dept Pediat, Div Crit Care, San Francisco, CA 94143 USA
[2] Childrens Hosp Philadelphia, Dept Pediat, Div Cardiol, Philadelphia, PA 19104 USA
[3] Childrens Hosp Philadelphia, Div Neurol, Dept Pediat, Philadelphia, PA 19104 USA
来源：
PROGRESS IN PEDIATRIC CARDIOLOGY | 2010年 / 29卷 / 02期
关键词：
Congenital heart defects; Brain development; White matter injury; Periventricular leukomalacia; Infant heart surgery; Fetal circulation;
D O I：
10.1016/j.ppedcard.2010.06.011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Brain and heart development occurs simultaneously in the fetus with congenital heart disease. Early morphogenetic programs in each organ share common genetic pathways. Brain development occurs across a more protracted time-course with striking brain growth and activity-dependent formation and refinement of connections in the third trimester. This development is associated with increased metabolic activity and the brain is dependent upon the heart for oxygen and nutrient delivery. Congenital heart disease leads to derangements of fetal blood flow that result in impaired brain growth and development that can be measured with advanced magnetic resonance imaging. Delayed development results in a unique vulnerability to cerebral white matter injury in newborns with congenital heart disease. Delayed brain development and acquired white matter injury may underlay mild but pervasive neurodevelopmental impairment commonly observed in children following neonatal congenital heart surgery. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：79 / 85
页数：7
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