We conducted a retrospective cohort study of mortality among current and former male employees of a modern tire manufacturing plant in Texas. Vital status was ascertained for more than 99% of the cohort of 2306 workers. Standardized mortality ratio analyses were completed based on 102 deaths. No significant excess for any disease-specific cause of death was identified, and significant deficits in all-cause mortality and deficits in cancer mortality were observed for both white and nonwhite men. The analyses were consistent in indicating that this work force has experienced no excessive disease-specific mortality.