FORMULATION AND EVALUATION OF METFORMIN ORODISPERSIBLE TABLETS

This study, the effect of using variable quantity of disintegrating agents like Crossceramilosesodium, Crospovidone, Sodium Starch Glycolate on the mouth dissolving property of Metformin tablets. Total five formulations in triplicate having disintegrants at variable amount were prepared by direct compression method. The tablets, were assessed if suitable as oral disintegrating tablets by determination of a range of technological parameters. Tablets were prepared by direct compression method and evaluated for hardness, thickness, friability, disintegration time, and percentage of drug release. It was observed that the formulation containing SSG were have better disintegrating property compared to other. Hardness of the tablets was found to be in the range of 3.4-3.9 kg/cm(2) for all formulations. The wetting time decreased with the increase in concentration of disintegrants. The tablets showed 97.52 +/- 0.46 % to 100.56 +/- 0.32 % of the labeled amount of drug, indicating uniformity in drug content. The in vitro dissolution time of various formulations was between 26.6 +/- 1.22 secs to 45.6 +/- 2.57 secs.