ALTERED MHC CLASS-I PRESENTED PEPTIDE REPERTOIRE IS NOT SUFFICIENT TO INDUCE NK CELL-MEDIATED F-1-HYBRID RESISTANCE

Murine NK cells are known to mediate F-1-hybrid anti-parental graft rejection responses. This phenomenon has been linked to the MHC, and in particular, to the alpha 1/alpha 2 domains of the MHC class I molecules. Here, we have addressed the role of MHC class I bound peptides in NK cell mediated F-1-hybrid anti-parental rejection by studying the resistance of F-1-hybrids between B6 and different bm mutant strains to B6-derived RBL-5 lymphoma cell line. Tumor development occurred at a similar frequency in all combinations of(B6 x bm)F-1 mice and control B6 mice. These results suggest that absence of a specific MHC class I presented peptide repertoire on grafted cells is not sufficient to induce NK cell mediated F-1-hybrid anti-parental rejection responses.