MACROMOLECULAR PRODRUGS .4. ALGINATE-CHITOSAN MICROSPHERES OF PHEA-L-DOPA ADDUCT

被引：19
|
作者：
FILIPOVICGRCIC, J [1 ]
MAYSINGER, D [1 ]
ZORC, B [1 ]
JALSENJAK, I [1 ]
机构：
[1] MCGILL UNIV, DEPT PHARMACOL & THERAPEUT, MONTREAL, PQ, CANADA
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 116卷 / 01期
关键词：
PHEA-L-DOPA ADDUCT; ALGINATE; CHITOSAN; MICROSPHERE; PRODRUG;
D O I：
10.1016/0378-5173(94)00269-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A polymeric prodrug alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide-L-dopa adduct (PHEA-L-dopa) was microencapsulated in alginate-chitosan microspheres in order to achieve drug release from a complex reservoir device. The gel/matrix material of alginate-chitosan complex protects the adduct from hydrolysis by the surrounding medium. On the basis of a 10(3)-fold difference between the drug released from microspheres as the adduct and that released in the unbound form, a model of the microencapsulated system was proposed.
引用
收藏
页码：39 / 44
页数：6
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