CLONING OF A TYPE-I TGF-BETA RECEPTOR AND ITS EFFECT OF TGF-BETA BINDING TO THE TYPE-II RECEPTOR

被引:413
|
作者
EBNER, R
CHEN, RH
SHUM, L
LAWLER, S
ZIONCHECK, TF
LEE, A
LOPEZ, AR
DERYNCK, R
机构
[1] UNIV CALIF SAN FRANCISCO, DEPT GROWTH & DEV, PROGRAM CELL BIOL, SAN FRANCISCO, CA 94143 USA
[2] GENENTECH INC, San Francisco, CA 94080 USA
[3] UNIV CALIF SAN FRANCISCO, VET ADM MED CTR, HEMATOL ONCOL SECT 111H, SAN FRANCISCO, CA 94121 USA
[4] UNIV CALIF SAN FRANCISCO, DEPT GROWTH & DEV, PROGRAM DEV BIOL, SAN FRANCISCO, CA 94143 USA
[5] UNIV CALIF SAN FRANCISCO, DEPT ANAT, SAN FRANCISCO, CA 94143 USA
[6] STANFORD UNIV, MED CTR, SCH MED, DEPT IMMUNOL, STANFORD, CA 94305 USA
关键词
D O I
10.1126/science.8388127
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Transforming growth factor-beta (TGF-beta) affects cellular proliferation, differentiation, and interaction with the extracellular matrix primarily through interaction with the type I and type II TGF-beta receptors. The type II receptors for TGF-beta and activin contain putative serine-threonine kinase domains. A murine serine-threonine kinase receptor, Tsk 7L, was cloned that shared a conserved extracellular domain with the type II TGF-beta receptor. Overexpression of Tsk 7L alone did not increase cell surface binding of TGF-beta, but coexpression with the type II TGF-beta receptor caused TGF-beta to bind to Tsk 7L, which had the size of the type I TGF-beta receptor. Overexpression of Tsk 7L inhibited binding of TGF-beta to the type II receptor in a dominant negative fashion. Combinatorial interactions and stoichiometric ratios between the type I and II receptors may therefore determine the extent of TGF-beta binding and the resulting biological activities.
引用
收藏
页码:1344 / 1348
页数:5
相关论文
共 50 条
  • [1] CLONING OF A TGF-BETA TYPE-I RECEPTOR THAT FORMS A HETEROMERIC COMPLEX WITH THE TGF-BETA TYPE-II RECEPTOR
    FRANZEN, P
    TENDIJKE, P
    ICHIJO, H
    YAMASHITA, H
    SCHULZ, P
    HELDIN, CH
    MIYAZONO, K
    [J]. CELL, 1993, 75 (04) : 681 - 692
  • [2] A MOUSE TGF-BETA TYPE-I RECEPTOR THAT REQUIRES TYPE-II RECEPTOR FOR LIGAND-BINDING
    SUZUKI, A
    SHIODA, N
    MAEDA, T
    TADA, M
    UENO, N
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 198 (03) : 1063 - 1069
  • [3] THE TYPE-II TGF-BETA RECEPTOR SIGNALS DIVERSE RESPONSES IN COOPERATION WITH THE TYPE-I RECEPTOR
    WRANA, JL
    CARCAMO, J
    ATTISANO, L
    CHEIFETZ, S
    ZENTELLA, A
    LOPEZCASILLAS, F
    MASSAGUE, J
    [J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1992, 57 : 81 - 86
  • [4] DETERMINATION OF TYPE-I RECEPTOR SPECIFICITY BY THE TYPE-II RECEPTORS FOR TGF-BETA OR ACTIVIN
    EBNER, R
    CHEN, RH
    LAWLER, S
    ZIONCHECK, T
    DERYNCK, R
    [J]. SCIENCE, 1993, 262 (5135) : 900 - 902
  • [5] CLONING OF AN ISOFORM OF MOUSE TGF-BETA TYPE-II RECEPTOR GENE
    SUZUKI, A
    SHIODA, N
    MAEDA, T
    TADA, M
    UENO, N
    [J]. FEBS LETTERS, 1994, 355 (01) : 19 - 22
  • [6] MOLECULAR ANALYSIS OF TGF-BETA SIGNAL-TRANSDUCTION - DOMINANT-INHIBITORY MUTATIONS OF THE TYPE-II AND TYPE-I TGF-BETA RECEPTOR
    SCHNEIDER, MD
    BRAND, T
    [J]. CARDIAC GROWTH AND REGENERATION, 1995, 752 : 309 - 316
  • [7] FUNCTIONAL-ANALYSIS OF THE TGF-BETA TYPE-II RECEPTOR
    WIESER, R
    ATTISANO, L
    WRANA, JL
    MASSAGUE, J
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 173 - 173
  • [8] TGF-beta type II receptor is essential for TGF-beta induced growth regulation.
    Zhao, Y
    Young, SL
    [J]. FASEB JOURNAL, 1996, 10 (03): : 151 - 151
  • [9] OVEREXPRESSION OF TGF-BETA-1, TGF-BETA-3 AND TGF-BETA RECEPTOR TYPE-II BUT NOT TO TGF-BETA-2 AND TGF-BETA RECEPTOR TYPE-III IN HUMAN LIVER-CIRRHOSIS
    FRIESS, H
    BERBERAT, P
    DEFLORIN, J
    BAER, HU
    GOLD, LI
    KORC, M
    BUCHLER, MW
    [J]. GASTROENTEROLOGY, 1995, 108 (04) : A1067 - A1067
  • [10] MOLECULAR-CLONING OF A MOUSE COUNTERPART FOR HUMAN TGF-BETA TYPE-I RECEPTOR
    TOMODA, T
    KUDOH, T
    NOMA, T
    NAKAZAWA, A
    MURAMATSU, M
    ARAI, K
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 198 (03) : 1054 - 1062