SYNTHETIC AND NMR-SPECTROSCOPIC INVESTIGATIONS OF BENZYLAMINE ADDITION TO N-MALEYLAMINO ACID-DERIVATIVES

被引：1
|
作者：
GRIEHL, C [1 ]
STROHL, D [1 ]
JESCHKEIT, H [1 ]
KLEINPETER, E [1 ]
机构：
[1] MARTIN LUTHER UNIV HALLE WITTENBERG,INST ANALYT CHEM,O-4010 HALLE,GERMANY
来源：
MONATSHEFTE FUR CHEMIE | 1992年 / 123卷 / 6-7期
关键词：
ALPHA-ASPARTYL PEPTIDES; NORMAL-MALEYLAMINO ACID DERIVATIVES; NUCLEOPHILIC ADDITION;
D O I：
10.1007/BF00816859
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
During the addition of amines to maleylamino acids in general beta-amino derivatives are formed. In order to change the reactivity within the vinylogous maleyl system we introduced the beta-benzylester group into the starting compound N-(cis-beta-carboxyacryloyl)-phenylalanine methylester 1. The obtained benzylester 2 is adding benzylamine in alpha-position yielding N-benzyl-alpha-aspartyl(beta-benzyl)-phenylalanine methylester 4. The addition reaction was investigated by H-1-NMR-spectroscopy. The structures of the compounds have been confirmed by elemental analysis, IR, H-1-NMR and C-13-NMR spectroscopy.
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页码：647 / 654
页数：8
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