Photo-thermal Ablation of Cancer by Using Photosensitive Nanoparticles

被引：0
|
作者：
Watanabe, Toshiyuki [1 ]
Tsubouchi, Mari [1 ]
Totani, Kenro [1 ]
Kamada, Kenji [2 ]
Iwase, Youichiro [3 ]
Kondo, Kouichi [3 ]
Kataoka, Kazunori [4 ]
机构：
[1] Tokyo Univ Agr & Technol, 2-24-16 Nakatyou, Koganei, Tokyo 1848588, Japan
[2] Natl Inst Adv Ind Sci & Technol, Tokyo, Japan
[3] Ritsumeikan Univ, Kyoto, Japan
[4] Univ Tokyo, Tokyo, Japan
来源：
NONLINEAR OPTICS QUANTUM OPTICS-CONCEPTS IN MODERN OPTICS | 2005年 / 34卷 / 1-4期
关键词：
Two-photon absorption cross section; Quantum yield; Nanoparticles; Block copolymer; Photothermal ablation;
D O I：
暂无
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
Two-photon initiated thermal ablation of cancer was investigated. Polymer nanoparticles consisting of two-photon chromophore were synthesized by using poly(ethyleneglycol)-poly(b-benzyl-L-aspartate) block copolymer. Mono dispersed nanoparticles having 70 nm diameters were obtained. In the case of MPPBT nanoparticle, quantum yield decreases and two-photon absorption cross section increases compared with that of MPPBT solution which is preferable for photo thermal ablation of cancer. Uptake of nanoparticles into Hela cell was confirmed by fluorescent imaging. FDA assay reveals that two-photon thermal ablation by using nanoparticles is effective for cancer therapy.
引用
收藏
页码：271 / 274
页数：4
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