THE CONTRIBUTION OF THE DIFFERENT BINDING-SITES OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR TO THE EXPRESSION OF BEHAVIOR

被引：63
|
作者：
KRETSCHMER, BD
ZADOW, B
VOLZ, TL
VOLZ, L
SCHMIDT, WJ
机构：
[1] Department of Neuropharmacology, Zoological Institute, University of Tübingen
来源：
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1992年 / 87卷 / 01期
关键词：
NMDA RECEPTOR; LOCOMOTION; CATALEPSY; STEREOTYPY; RAT; CGP37849; DIZOCILPINE (MK-801); GLYCINE; D-CYCLOSERINE;
D O I：
10.1007/BF01253108
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of competitive (CGP37849 and CGP39551) and noncompetitive (dizocilpine) N-methyl-D-aspartate (NMDA) antagonists were tested in three animal models (catalepsy, sniffing, locomotion) and, in addition, the modulation of these effects by an agonist of the strychnine-insensitive glycine binding site was investigated. Both competitive and non-competitive NMDA antagonists reduced neuroleptic-induced catalepsy. Weak sniffing was induced by the competitive antagonist but strong sniffing by the non-competitive NMDA antagonist. Due to muscle relaxation the competitive antagonist reduced locomotion, in contrast to stimulation of locomotor activity induced by the noncompetitive NMDA antagonist. The glycine agonist (D-cycloserine) potentiated the effects of the non-competitive but antagonized those of the competitive NMDA antagonist.
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收藏
页码：23 / 35
页数：13
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