A STRAIGHT CORRELATION BETWEEN MUTAGENIC ACTIVITY AND BETA-GALACTOSIDASE ACTIVITY INDUCED BY MONOFUNCTIONAL ALKYLATING-AGENTS

被引：1
|
作者：
OHTSUKA, M
MAEKAWA, K
机构：
[1] Hita Research Laboratories, Chemicals Inspections and Testing Institute, Hita, Oita, 877, 822, 3-chome, Ishii-machi
来源：
MUTATION RESEARCH | 1992年 / 283卷 / 01期
关键词：
ALKYLATING AGENT; MUTATION INDUCTION; SALMONELLA PREINCUBATION ASSAY;
D O I：
10.1016/0165-7992(92)90126-3
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Eight monofunctional alkylating agents were examined for their ability to induce mutation in Salmonella typhimurium. The assay was carried out in S. typhimurium TA100 with the preincubation method. The S(N)1-type agents were more mutagenic than the S(N)2-type ones; besides, methylating agents exerted more mutagenic activity than ethylating ones. Those responses in the reversion assay were quite similar to the results obtained previously with the beta-galactosidase assay in Escherichia coli CSH26/pMCP1000 (alkA'-lacZ') as to the induction of the adaptive response. A good correlation was found between, mutagenic potency in the reverse mutation assay and inducing potency in the beta-galactosidase assay.
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页码：83 / 86
页数：4
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