INFLUENCE OF TOLFENAMIC ACID ON AIRWAY CONTRACTILITY IN GUINEA-PIGS

被引：0
|
作者：
RYDBERG, IGM
ANDERSSON, RGG
机构：
[1] Department of Pharmacology, Faculty of Health Sciences, Linköping University, Linköping
来源：
PHARMACOLOGY & TOXICOLOGY | 1994年 / 75卷
关键词：
D O I：
10.1111/j.1600-0773.1994.tb01993.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of the NSAIDs tolfenamic acid and indomethacin was tested on acetylcholine-induced and antigen-induced contractions in guinea pig airways. Indomethacin potentiated antigen-induced contractions while tolfenamic acid showed dilatory properties. The effect of the drugs on acetylcholine-induced contractions showed no significant differences; indomethacin had a slightly increasing tendency while tolfenamic acid reduced the contractile response. These results indicate that tolfenamic acid does not have bronchoconstrictive properties, which is a common side effect of other NSAIDs in asthmatics.
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页码：33 / 36
页数：4
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