MANGANESE TOXICITY - MUSCARINIC RECEPTOR-BINDING IN THE MOUSE-BRAIN

In the present study we determined the effect of repeated administration of manganese chloride on the binding parameters of [H-3]quinuclidinyl benzilate (H-3-QNB) in striatum, frontal cortex, and hippocampus of mice. Daily intraperitoneal injections of manganese chloride (5 mg Mn/kg) 5 d/wk during 9 wk did not alter the receptor density (B-max) and the dissociation constant (K-d) H-3-QNB in the different brain regions studied. These results suggest that chronic treatment with manganese does not affect the binding characteristics of H-3-QNB to the cholinergic muscarinic receptors in mouse brain.